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Avera Institute for Human Genetics

3720 W. 69th Street Suite 200
Sioux Falls, SD 57108
Phone: 605-322-3050


Dr. Gareth Davies

Scientific Director

Gareth Davies, PhD, is a Human Molecular Geneticist with expertise in complex diseases and gene expression.

Research Interests

This information will be available soon.

Professional Memberships

  • International Society of Psychiatric Genetics
  • The American Society for Human Genetics
  • American Association of Immunologists
  • AACP
  • The Obesity Society
  • Sigma Xi
  • Rho Chi
  • Kappa Psi


Mbarek H, Steinberg S, Nyholt DR, Gordon SD, Miller MB, McRae AF, Hottenga JJ, Day FR, Willemsen G, de Geus EJ, Davies GE, Martin HC, Penninx BW, Jansen R, McAloney K, Vink JM, Kaprio J, Plomin R, Spector TD, Magnusson PK, Reversade B, Harris RA, Aagaard K, Kristjansson RP, Olafsson I, Eyjolfsson GI,Sigurdardottir O, Iacono WG, Lambalk CB, Montgomery GW, McGue M, Ong KK, Perry JR, Martin NG, Stefansson H, Stefansson K, Boomsma DI. Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. Am J Hum Genet. 2016 May 5;98(5):898-908. Click here for the abstract.

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh, AM, et al. Genetic Influences on Schizophrenia and Subcortical Brain Volumes: Large-Scale Proof of Concept. Nat Neurosci. 2016 Mar;19(3):420-31. van Dongen J, Nivard MG, Willemsen G, Hottenga JJ, Helmer Q, Dolan CV, Ehli EA, Davies GE, van Iterson M, Breeze CE, Beck Stephen, BIOS Consortium, Suchiman HE, Jansen R, van Meurs JB, Heilmans BT, Slagboom PE, Boomsma DI. Genetic and Environmental Influences Interact with Age and Sex in Shaping the Human Methylome. Nat Commun. 2016 Apr 7;7:11115. Click here for the full article.

San Lucas FA, Allenson K, Bernard V, Castillo J, Kim DU, Ellis K, Ehli EA, Davies GE, Petersen JL, Wolff R, Katz M, Varadhachary G, Wistuba I, Maitra A, Alvarez H. Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes. Ann Oncol. 2015 Dec 17. [Epub ahead of print] Click here for the full article.

Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, Nolte IM, Tiesler CM, Bakermans-Kranenburg MJ, Davies GE, Evans DM, Geoffroy MC, Grallert H, Groen-Blokhuis MM, Hudziak JJ, Kemp JP, Keltikangas-Järvinen L, McMahon G, Mileva-Seitz VR, Motazedi E, Power C, Raitakari OT, Ring SM, Rivadeneira F, Rodriguez A, Scheet PA, Seppälä I, Snieder H, Standl M, Thiering E, Timpson NJ, Veenstra R, Velders FP, Whitehouse AJ, Smith GD, Heinrich J, Hypponen E, Lehtimäki T, Middeldorp CM, Oldehinkel AJ, Pennell CE, Boomsma DI, Tiemeier H. A genome-wide approach to children's aggressive behavior: The EAGLE Consortium. Am J Med Genet B Neuropsychiatr Genet. 2015 Jun 18. [Epub ahead of print] Click here for the abstract.

Fedko IO, Hottenga JJ, Medina-Gomez C, Pappa I, van Beijsterveldt CE, Ehli EA, Davies GE, Rivadeneira F, Tiemeier H, Swertz MA, Middeldorp CM, Bartels M, Boomsma DI. Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height. Behav Genet. 2015 Jun 3. [Epub ahead of print] Click here for the abstract.

Hansell NK, Halford GS, Andrews G, Shum DHK, Harris SE, Davies G, Franic S, Christoforou A, Zietsch B, Painter J, Medland SE, Ehli EA, Davies GE, Steen VM, Lundervold AJ, Reinvang, Montgomery GW, Espeseth T, et al. Genetic Basis of a Cognitive Complexity Metric. PLoS ONE. 2015;10(4):e0123886. Click here for the full article.

Abdellaoui A, Hottenga JJ, Willemsen G, Bartels M, van Beijsterveldt T, Ehli EA, Davies GE, Brooks A, Sullivan PF, Penninx BWJH, de Geus EJ, Boomsma DI. Educational Attainment Influences Levels of Homozygosity through Migration and Assortative Mating. PLoS ONE. 2015;10(3):e0118935. Click here for the full article.

Hibar DP, Davies GE, Boomsma DI, Medland SE, et al. Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 9;520(7546):224-229. Click here for the article.

Abdellaoui A, Ehli E, Hottenga JJ, Weber Z, Mbarek H, Willemsen G, von Beijsterveldt T, Brooks A, Hudziak JJ, Sullivan PF, de Geus EJ, Davies GE, Boomsma DI. CNV Concordance in 1,097 MZ Twin Pairs. Twin Res Hum Genet. 2015 Jan 12:1-12. [Epub ahead of print] Click here for the abstract.

Franic S, Dolan CV, Broxholme J, Hu H, Zemojtel T, Davies GE, Nelson KA, Ehli EA, Pool R, Hottenga JJ, Childhood Intelligence Consortium, Ropers HH, Boomsma DI. Medelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence. Intelligence. 2015;49:10-22.

Groen-Blokhuis MM, Middeldorp CM, Kan K, Abdellaoui A, van Beijsterveldt CEM, Ehli EA, Davies GE, Scheet PA, Xiao X, Hudziak JJ, Hottenga J, Psychiatric Genomics Consortium ADHD Working Group, Neale BM, Boomsma DI. Attention Deficit Hyperactivity Disorder polygenic risk scores predict Attention Problems in a population-based sample of children. J Am Acad Child Psy. 2014 Oct;53(10):1123-9. Click here for the abstract.

Huppertz C, Bartels M, Groen-Blokhuis M, Dolan C, de Moor M, Abdellaoui A, van Beijsterveldt T, Ehli EA, Hottenga J, Willemsen G, Xiao X, Scheet P, Davies G, Boomsma D, Hudziak J, de Geus E. The dopaminergic reward system and leisure time exercise behavior: a candidate allele study. BioMed Research International. 2014. Epub 2014 Mar 9. Click here to read the free article.

Hu Y, Young AJ, Ehli EA, Nowotny D, Davies PS, Droke EA, Soundy TJ, Davies GE. Metformin and berberine prevent olanzapine-induced weight gain in rats. PLoS ONE. 2014;9(3):e93310. Click here to read the free article.

van Dongen J, Ehli EA, Slieker RC, Bartels M, Weber ZM, Davies GE, Slagboom PE, Heijmans BT, Boomsma DI. Epigenetic variation in monozygotic twins: A genome-wide analysis of DNA methylation in buccal cells. Genes (Basel). 2014;5(2):347-65. Click here to read the free article.

de Zeeuw EL, van Beijsterveldt CEM, Glasner TJ, Ehli EA, Davies GE, Hudziak JJ, Social Science Genetic Association Consortium, Rietveld NA, Groen-Blokhuis MM, Hottenga J, de Geus EJC, Boomsma DI. Polygenic scores associated with educational attainment in adults predict educational achievement and attention problems in children. Am J Med Genet B Neuropsychiatr Genet. 2014 Sep; 165(6):510-20. Click here for the abstract.

Abdellaoui A, Hottenga JJ, Xiao X, Scheet P, Ehli EA, Davies GE, Hudziak JJ, Smit DJA, Bartels M, Willemsen G, Brooks A, Sullivan PF, Smit JH, de Geus EJ, Phenninx BW, Boomsma D. Association Between Autozygosity and Major Depression: Stratification Due to Religious Assortment. Behav Genet. 2013;43(6):455-467. Click here for the abstract.

Groen-Blokhuis MM, Franic S, van Beijsterveldt CE, de Geus E, Bartels M, Davies GE, Ehli EA, Xiao X, Scheet PA, Althoff R, Hudziak JJ, Middeldorp CM, Boomsma DI. A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. Am J Med Genet B Neuropsychiatr Genet. 2013 Jul;162(5):457-65. Click here for the abstract.

Abdellaoui A, Hottenga JJ, Knijff PD, Nivard MG, Xiao X, Scheet P, Brooks A, Ehli EA, Hu Y, Davies GE, Hudziak JJ, Sullivan PF, van Beijsterveldt T, Willemsen G, de Geus EJ, Penninx BW, Boomsma DI. Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet. 2013 Mar 27. [Epub ahead of print] Click here for the abstract.

van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. Twin Res Hum Genet. 2013 Feb;16(1): 252-67. Click here for the abstract.

Geels LM, Groen-Blokhuis MM, van Beijsterveldt CE, Vink JM, Middeldorp CM, Bartels M, Nelson KA, Huizenga PE, Davies GE, Boomsma DI. Maternal prenatal smoking and offspring emotional problems: no moderating effect of maternal or child 5-HTTLPR genotype. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):1009-12. doi: 10.1002/ajmg.b.32110. Epub 2012 Oct 22. Click here for the abstract.

Scheet P, Ehli EA, Xiao X, van Beijsterveldt CE, Abdellaoui A, Althoff RR, Hottenga JJ, Willemsen G, Nelson KA, Huizenga PE, Hu Y, Amos CI, Bartels M, Groen-Blokhuis MM, de Geus EJ, Hudziak JJ, Davies GE, Boomsma DI. Twins, tissue, and time: an assessment of SNPs and CNVs. Twin Res Hum Genet. 2012 Dec;15(6):737-45. Click here for the abstract.

Ehli EA, Abdellaoui A, Hu Y, Hottenga JJ, Kattenberg M, van Beijsterveldt T, Bartels M, Althoff RR, Xiao X, Scheet P, de Geus EJ, Hudziak JJ, Boomsma DI, Davies GE. De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems. Eur J Hum Genet. 2012 Oct;20(10):1037-43. Click here for the abstract.

Hu Y, Ehli EA, Hudziak JJ, Davies GE. Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region. Pharmacogenomics J. 2012 Oct;12(5):372-8. Click here for the abstract.

Hu Y, Ehli EA, Kittelsrud J, Ronan PJ, Munger K, Downey T, Bohlen K, Callahan L, Munson V, Jahnke M, Marshall LL, Nelson K, Huizenga P, Hansen R, Soundy TJ, Davies GE. Lipid-lowering effect of berberine in human subjects and rats. Phytomedicine. 2012 Jul 15;19(10):861-7. Click here for the abstract.

Hu Y, Ehli EA, Nelson K, Bohlen K, Lynch C, Huizenga P, Kittlelsrud J, Soundy TJ, Davies GE. Genotyping performance between saliva and blood-derived genomic DNAs on the DMET array: a comparison. PLoS One. 2012;7(3):e33968. Click here for the abstract.

Ehli EA, Hu Y, Lengyel-Nelson T, Hudziak JJ, Davies GE. Identification and functional characterization of three novel alleles for the serotonin transporter-linked polymorphic region. Mol Psychiatry. 2012 Feb; 17(2):185-192. Click here for the abstract.

Stoltenberg SF, Lehmann MK, Christ CC, Hersrud SL, Davies GE. Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms. Drug Alcohol Depend. 2011 Dec 15;119(3):e31-8. Click here for the abstract.

Hu Y, Kutscher E, Davies GE. Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells. Phytotherapy Res. 2010 Dec 24(12):1831-8. Click here for the abstract.

Albaugh MD, Harder VS, Althoff RR, Rettew DC, Ehli EA, Lengyel-Nelson T, Davies GE, Ayer L, Sulman J, Stanger C, Hudziak JJ. COMT Val158Met genotype as a risk factor for problem behaviors in youth. J Am Acad Child Adolesc Psychiatry. 2010 Aug;49(8):841-9. Click here for the abstract.

Hu Y, Davies GE. Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Fitoterapia. 2010 Jul;81(5):358-66. Click here for the abstract.

Kumar A, Yellepeddi VK, Davies GE, Strychar KB, Palakurthi S. Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues. Int J Pharm. 2010 Jun 15;392(1-2):294-303. Click here for the abstract.

Hu Y, Fahmy H, Zjawiony J, Davies GE. Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation. Fitoterapia. 2010 Jun;81(4):259-268. Click here for the abstract.

Hu Y, Davies GE. Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. Phytomedicine. 2009 Sep;16 (9):864-73. Click here for the abstract.

Kutscher E, Davies GE. Pharmacogenomics: Has our history become Modern Medicine? S D Med. 2009 Apr:62(4);160-161.

Ehli EA, Lengyel-Nelson T, Hudziak JJ, Davies GE. Using a commercially available DNA extraction kit to obtain high quality human genomic DNA suitable for PCR and genotyping from 11-year-old saliva saturated cotton spit wads. BMC Res Notes. 2008 Dec 22;1(1):133. Click here to read the free article.

Davies GE, Locke SM, Wright PW, Li H, Hanson RJ, Miller JS, Anderson SK. Identification of bidirectional promoters in the human KIR genes. Genes Immun. 2007 Apr;8(3):245-53. Click here for the abstract.

Davies GE, Saleh A, Pascal V, Wright PW, Hodge DL, Cho EH, Lockett SJ, Abshari M, Anderson SK. Identification of probabilistic transcriptional switches in the Ly49 gene cluster: A eukaryotic mechanism for selective gene activation. Immunity. 2004 Jul;21(1):55-66. Click here for the abstract.

Pascal V, Davies GE, Anderson SK. A critical role for NFκB/p65 in establishing the Ly49 gene cluster. Clin Invest Med. 2004;27(4).

Anderson SK, Pascal V, Davies GE. A molecular explanation for stochastic receptor expression: probabilistic switches. Clin Invest Med. 2004;247(4).

Hessner MJ, Vaughan K, Meyer L, Davies GE, Nye S, Wang X, Ghosh S. Gene expression profiling in the diabetic prone (DP) and diabetic resistant (DR) biobreeding rat. Diabetes. 2002;51(Suppl 1):257S.

Davies GE, Sabatakos G, Cryer A, Ramji DP. The Ovine CCAAT-Enhancer Binding Protein delta Gene: Cloning, Characterization, and Species-Specific Autoregulation. Biochem Bioph Res Co. 2000 May; 271(2):346-352. Click here for the abstract.

Sabatakos G, Davies GE, Grosse M, Cryer A, Ramji DP. Expression of the genes encoding the CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution. Biochem J. 1998 Aug;334(1):205-210. Click here for the abstract.