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Avera Research Institute

2020 S. Norton Ave.
Sioux Falls, SD 57105
605-322-3050

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Oncology Studies

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Avera McKennan Foundation

Oncology Studies

Following is a complete list of oncology studies currently enrolling patients.

Brain Cancer Studies

NCCTG N0877 -- Phase I/Randomized Phase II Trial of Either Dasatinib or Placebo Combined with Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM)
NCCTG N0872 -- Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma

Breast Cancer Studies

SWOG S1007 -- Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER-2 Negative Breast Cancer with Recurrence Score (RS) of 25 or Less
NSABP B-43 -- Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy
ECOG E2108 -- A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer
NSABP B-49 -- Phase III Clinical Trial Comparing the Combination of Docetaxel plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
RTOG 1005 -- Higher-Dose Radiation Therapy or Standard Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery
SWOG S1207 -- Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer
A Phase III Randomized, Double-Blind, Placebo-Controlled Study of BKM120 with Fulvestrant, in Postmenopausal Women with Hormone Receptor-Positive HER2-Negative AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or after mTOR Inhibitor-Based Treatment (BELLE-3)
Impact of Breast Conservation Surgery on Surgical Outcomes and Cosmesis in Patients with Multiple Ipsilateral Breast Cancers (MIBC)
Hypofractionated Whole-Breast Irradiation Preceded by Intra-Operative Radiotherapy with Electrons as the Anticipated Boost (HIOB)
Breast Cancer Biomarker Sample Collection for the DtectDx Assay Proof of Concept Protocol
NSABP B-50-I/B027938 -- A Randomized, Multicenter, Open Label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine versus Trastuzumab as Adjuvant Therapy for Patients with HER-2-Positive Primary Breast Cancer Who Have Residual Tumor Present Pathologically in the Breast or Axillary Lymph Nodes following Preoperative Therapy

Colon Cancer Studies

CTSU C80702 -- A Phase III Trial of 6 versus 12 Treatments of Adjuvant FOLFOX plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cance
A Pivotal Phase III Study to Evaluate Overall Survival Using MABp1 as a Monotherapy in Metastatic Colorectal Cancer Patients with Cachexia

Esophageal Cancer Studies

SWOG S1201 -- A Randomized, Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric or Gastroesophageal Junction (GEJ) Cancer

Gynecologic Cancer Studies

Head & Neck Cancer Studies

ECOG E1305 -- Phase III Randomized Trial of Chemotherapy with or without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer

Leukemia Studies

Liver Cancer Studies

CTSU C80802 -- Phase III Randomized Study of Sorafenib plus Doxorubicin versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma (HCC)

Lung Cancer Studies

ECOG E1505 -- Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Lung Cancer That Was Removed By Surgery
ECOG E5508 -- Randomized Phase III Study of Maintenance Therapy with Bevacizumab, emetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous Non-Small Cell Lung Cancer
SWOG S0819 -- Carboplatin/Paclitaxel With or Without Bevacizumab and/or Cetuximab in Stage IV or Recurrent Non-Small Cell Lung Cancer
Phase II Study of the Weekly Vinorelbine and Paclitaxel in Elderly Patients with Advanced Non-Small Cell Lung Cancer
Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy

Lymphoma Studies

Phase II/III Multi-center, Randomized Open-label Study to Compare the Efficacy and Safety of Lenalidomide versus Investigator's Choice in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
SWOG S1108 -- Phase II Trial of the Aurora Kinase A Inhibitor MLN8237, in Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma
A Phase III, Open-Label, Multi-Center, Randomized Study of Sequential Zevalin Versus Observation in Patients at Least 60 Years of Age with Newly Diagnosed Diffuse Large B-Cell Lymphoma in PET-Negative Complete Remission After R-CHOP or R-CHOP-like Therapy

Melanoma

ECOG E1609 -- A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy versus High-Dose Interferon a-2b for Resected High-Risk Melanoma

Multiple Myeloma

A Multi-Center, Single-Arm, Open-Label Treatment Use Program for Pomalidomide (POM) in combination with Low Dose Dexamethasone (LD-DEX) in Subjects with Relapsed or Refractory Multiple Myeloma
Randomized, Double-Blind, Multi-Center Study of Denosumab Compared with Zoledronic Acid in the Treatment of Bone Disease in Subjects with Newly Diagnosed Multiple Myeloma
ECOG E3A06 -- Randomized Phase III Trial of Lenalidomide Versus Observation Alone in Patients with Asymptomatic High-Risk Smoldering Multiple Myeloma
A Phase III, Randomized Open Label Trial of Lenalidomide/Dexamethasone with or without Elotuzumab in Subjects with Previously Untreated Multiple Myeloma

Pancreatic Cancer Studies

SWOG S1115 -- Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy

Renal/Urinary Tract Cancer Studies

CALGB C90601 -- Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin and Bevacizumab to Gemcitabine, Cisplatin and Placebo in Patients with Advanced Transitional Cell Carcinoma
SWOG S0931 -- EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy, a Phase III Study

Transplant/Transfusion Studies

BMT CTN 0301 -- Fludarabine Based Conditioning for Allogeneic Marrow Transplantation for HLA-Compatible Unrelated Donors in Severe Aplastic Anemia
CIBMTR 06 DON -- RDSafe: A Multi-Center Study of Hematopoietic Stem Cell Donor Safety and Quality of Life
Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation with Unrelated Donors
Defibrotide for Patients with Hepatic Veno-Occlusive Disease (VOD): a Treatment IND Study

Cancer Control Studies

NCCTG N07C4 -- Phase II Trial Evaluating Two Non-Pharmacologic Interventions in Cancer Survivors for the Treatment of Sleep-Wake Disturbances
NSABP P-5 -- Statin Polyp Prevention Trial in Patients with Resected Colon Cancer
Acupuncture for Menopausal Hot Flashes

Cancer Registry Studies

The Multiple Myeloma Disease Registry for Patients with Newly-Diagnosed Symptomatic Multiple Myeloma
Development and Implementation of the Breast Cancer Collaborative Registry (BCC R)
A Registry of Sipuleucel-T Therapy in Men with Advanced Prostate Cancer

Studying Interventions for Managing Patients with Chronic Myeloid Leukemia in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY)

Development and Implementation of the Thyroid Tumor and Cancer Collaborative Registry (TCCR)

Currently Enrolling Studies

Breast Cancer
Collaborative Registry
The BCCR helps researchers study the factors that influence the risk of developing breast cancer.

Other currently enrolling studies

Avera Institute for Human Genetics

Avera IHG is the premier research program for psychiatric disease in the region.

Avera IHG details

National Institute of Mental Health Outreach Partnership Program

View updates regarding our partnership program and other available resources.