About Me

The love of science and a desire to care for others drew Mark Huber, MD, to a career in medicine. In fact, the best advice in medical school he received was to “go into something you love to read about.”

Without a doubt, that was cancers and disorders of the blood, he said, as this helps him stay on the forefront of medical advancements as he delivers compassionate care.

Dr. Huber is a medical oncologist at Avera Medical Group Oncology & Hematology in Sioux Falls, SD. Here, he has cultivated a distinguished practice of treating a variety of cancers and working with specialists from each of these areas.

Expert Care in Cancer Care

Dr. Huber collaborates with his multidisciplinary team to give patients facing cancer the best care possible. Personalized treatment plans may include:

  • Chemotherapy
  • Immunotherapy
  • Targeted therapy
  • Supportive and holistic care

However, for Dr. Huber, an integral part to effective cancer care is building good relationships with patients.

“It’s like the old adage: to treat them how you would a family member,” he said, “to respect their opinion and what they have to say.”

Active Lifestyle

When he’s not at work, Dr. Huber enjoys exercising. Running is his main go-to, though he says he’s “not as fast as I used to be.” He also enjoys spending time with his family.

Special Interests

All solid tumors, hematological cancers (lymphoma, multiple myeloma), and blood or clotting disorders

Experience

Education

Medical College of Georgia, Augusta, Medical School

Residency

Mayo Graduate School of Medicine, Rochester, MN, Internal Medicine

Fellowship

Mayo Graduate School of Medicine, Rochester, MN, Medical Oncology and Hematology

Certifications

  • American Board of Internal Medicine - Medical Oncology and Hematology

Reviews

We value patient feedback and are committed to providing you with information, so you can make informed decisions about your health care, physicians and other providers in your care journey. Patient ratings and comments are gathered from the post-visit experience survey. Learn more.

October 24, 2025
The staff and the providers all were excellent
October 19, 2025
Dr. Huber is an excellent physician - very knowledgeable, professional, and most portable, very concerned about his patients.
October 17, 2025
He's always been good for me
October 11, 2025
Friendly and knowledgeable
October 07, 2025
Dr. Huber and his staff have all done well in my series of chemo infusions since first starting back in Feb.!!Dr. Huber has always listened to my concerns and has given us [ husband ] straight answers as to what is plan [s]For the next processes needed for my cancer...
October 06, 2025
Dr. Huber is a great doctor! I feel happy that he is one of my caregivers.
October 05, 2025
Good so far
October 04, 2025
Good experience
October 03, 2025
Everything was very friendly and efficient
October 02, 2025
I'm very happy with Avera. They take care to make sure I don't have any problems understanding my options.
October 01, 2025
Excellent
September 28, 2025
Amazing care! Thank you!
September 27, 2025
I like that Dr. Huber listened carefully then looked ME (not my husband) in the eye as he responded to my inquiries.
September 21, 2025
Dr, Huber was very thorough, patient and professional answering all my questions.
September 21, 2025
Dr Huber has been very helpful with my cancer.
September 16, 2025
Telemedicine conference went very smoothly and very clear and concise.
September 14, 2025
Wonderful service! Thank you!!!
September 11, 2025
Love Dr. Huber. He tells it like it is.
September 02, 2025
Dr. Huber and nurse always made me feel comfortable asking questions, we're incredibly knowledgeable, and related the info to me in a way I could comprehend.
August 27, 2025
Pro team!!!!
August 24, 2025
Keep up the good work
August 23, 2025
Good experience with entire staff.Friendly and helpful.
August 16, 2025
The best all of them. Very careing.
August 12, 2025
It was very smooth.
August 11, 2025
A-plus
August 09, 2025
Dr Huber was great through my entire cancer journey!!!
July 30, 2025
Always explains everything and never seems rushed
July 19, 2025
Very awkward appointment with dr
July 06, 2025
Dr Huber is exceptional ! Definitely recommend him for other patients
June 28, 2025
Great
June 05, 2025
It's always friendly and easy.
May 17, 2025
Good
May 16, 2025
Excellent service
March 26, 2025
Dr. Huber is wonderful. You are blessed to have him.
March 02, 2025
I cannot say enough about the effort and care provided.

Directory Disclaimers

This directory contains information about the provider members of Independent Health Care Associates, Avera Health and all Avera entities, members of the Avera Medical Group, and employed select providers with Avera McKennan, Sioux Falls, SD and Avera Marshall, Marshall, MN and physicians with hospital privileges at Avera St. Luke's, Aberdeen, SD; Avera Sacred Heart, Yankton, SD; Avera Queen of Peace, Mitchell, SD; Avera St. Mary's, Pierre, SD.

Non-Avera web sites (e.g., Facebook, Twitter, etc.) linked to from this Web page, including any blogs or other personal, networking or social media Web sites, are not affiliated with, nor endorsed by any Avera facility. Opinions, views, and comments posted on these Web sites are not Avera's.  Avera assumes no legal liability or responsibility for the accuracy, completeness, or usefulness of any information, product, or process disclosed on these sites. The opinions of those posting comments, views or opinions on these sites do not necessarily state or reflect those of Avera and shall not be used for advertising or product endorsement purposes.