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1325 S Cliff Avenue Suite CP Sioux Falls, SD 57105

Hours of Operation

Sunday - 9:00AM-5:00PM
Monday - 8:00AM-5:30PM
Tuesday - 8:00AM-5:30PM
Wednesday - 8:00AM-5:30PM
Thursday - 8:00AM-5:30PM
Friday - 8:00AM-5:30PM
Saturday - 9:00AM-5:00PM

Featured Health Services

Avera Pharmacy

Avera Pharmacy on Cliff Avenue in Sioux Falls provides convenient pharmacy services for the public, discharged patients and employees, right in the primary skywalk that connects several of Avera McKennan’s parking areas and plazas.

Important Service Adjustments

To best protect our patients, our staff and all our families during the COVID-19 pandemic, we encourage you to have your health care provider call, fax, or e-prescribe new and refill prescriptions. Avera Pharmacies also encourage you to use our free mail or shipping options. Our 24/7 Pharmacy Kiosk also provides a convenient way to pick up your prescriptions and common over-the-counter items while maintaining social distancing. Call your Avera Pharmacy with questions or to arrange for this free service. You can also select shipping in the Avera Rx app.

This pharmacy offers complete prescription service as well as a convenient and varied selection of over-the-counter retail products.

To transfer your prescription, please call 605-322-8326.

Purchase Over-the-Counter Medications 

When you fill a prescription at Avera Pharmacy, order all your over-the-counter medications and supplements for added convenience. Shipping is free on all orders!

Download the Avera Rx App

For a simple and convenient way to manage medications – for your entire family – sign up for AveraRx. With a free AveraRx account, you can easily:

  • Order refills
  • Receive a message when your prescription is ready
  • Set up reminders to take your medications
  • View an up-to-date list of your prescriptions

Download on the App Store

Get it on Google Play

Avera Rx Desktop link button

Already have an AveraRx account? Login from your computer here.

Sign Up for Text Alerts

When you sign up for Avera Pharmacy’s text alerts program, you’ll receive notifications about: 

  • Refill reminders
  • Problems with insurance, inventory issues, etc.
  • Credit card issues
  • Home deliveries on the way
  • Immunization reminders
  • Pick-up reminders

You must sign up for text alerts at your local Avera Pharmacy location and provide your cell phone number.

Call Ahead for your Prescription

Have your prescription ready when you arrive by calling 605-322-8326 or toll-free at 800-568-6579.

24/7 Script Center Pharmacy Kiosk

Do you need to pick up your prescription but can’t make it to the pharmacy during open hours? Sign up for 24/7 Script Center Pharmacy Kiosk access today. Simply enter your information on the kiosk screen, and you’ll receive your prescription dispensed using the handy, after-hours kiosk. Located by the hospital campus pharmacy, the kiosk is the perfect solution for ensuring you receive needed prescriptions when it works for you. 

Stop by the 24/7 Script Center Pharmacy Kiosk to sign up for free or ask your Avera pharmacist how to get started.

Dispose of Your Unused Medication

Want to safely throw away unused or expired medications? Learn about blue, drop-off MedSafe receptacles available at most Avera Pharmacy locations during regular pharmacy hours.

Moving Health Forward

Avera is a health ministry rooted in the Gospel. Our mission is to make a positive impact in the lives and health of persons and communities by providing quality services guided by Christian values.

© 2022 Avera Health, Sioux Falls, SD. All Rights Reserved.