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A Phase 2/3, Interventional safety, pharmacokinetics, and efficacy, open-label, multi-center, single-arm study to investigate orally administered PF-07321332 (Nirmatrelvir)/Ritonavir in non-hospitalized symptomatic pediatric participants with COVID-19 who are at risk of progression to severe disease
To compare the efficacy of nirmatrelvir (PF-07321332)/ritonavir to placebo for the treatment of symptomatic COVID-19 in non- hospitalized pediatric participants with COVID-19 who are at risk of progression to severe disease. Patients are randomized 1:1 and will receive placebo or the investigational product orally for 5 days. Patients will complete in-person and remote follow-up visits including assessments such as nasopharyngeal swabs, blood draws, and physical exams.
A Phase IIIB, Randomized, Observer-blind, Multicenter Study to Assess the Safety and Immunogenicity of GSK Meningococcal Group B Vaccine when Administered Concomitantly with GSK Meningococcal MenACWY Conjugate Vaccine to Healthy Subjects 16-18 Years of Age.
Meningococcal Group B Vaccine trial for teens, ages 16-18 years.
Bronchiolitis Recovery and the Use of High Efficiency Particulate Air (HEPA) Filters (BREATHE)
Children <12 months of age hospitalized with bronchiolitis are randomized to receive a 24-week home intervention with filtration units containing HEPA &carbon filters to improve indoor air quality or to a control group with filtration units without HEPA and carbon filters.
Improving Pediatric COVID-19 Vaccine Uptake Using an mHealth Tool (MoVeUP)
This study will determine the effectiveness of a vaccine communication mobile health app on parental decisions to vaccinate their children against COVID-19.
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)
The study investigators are interested in learning more about how drugs act in the bodies of children and young adults in hopes to find the most safe and effective dose for children.

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