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Phase 3, Open-Label, Randomized Study of Perioperative Dostarlimab Monotherapy vs Standard of Care in Pts With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Assess adverse events disease activity comparing IV infused ABBV-400 to LONSURF oral tablets plus IV bevacizumab in adult participants with metastatic colorectal cancer
Assess adverse events and change in disease activity when ABBV-400 is given in combo with Fluorouracil, Folinic Acid and Bevacizumab to adults to treat colorectal cancer
Phase 2/3 trial will evaluate which chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer
If tucatinib w/ other cancer drugs works better than SOC to treat HER2 positive colorectal cancer. Also looks at side effects that happen with this combination of drugs.