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Accepting Participants (7)

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BI 1479-0012 (Beamion BCGC-1): A Phase Ib Dose Escalation and Phase II Dose Optimization, Randomized, Open-label, Multicenter Trial of Oral Zongertinib (BI 1810631) Alone or in Combination With Other Agents for the Treatment of Patients With Advanced HER2+ Metastatic Breast Cancer (mBC), Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (mGEAC), or Metastatic Colorectal Cancer (mCRC)
Phase II Trial of Oral Zongertinib Alone/Combo W/Other Agents for Pts w/Adv HER2+ mBC, met. Gastric, GJ, mGEAC, or mCRC
C6461003: AN INTERVENTIONAL, PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS BEVACIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN TREATMENT-NAÏVE PARTICIPANTS WITH METASTATIC COLORECTAL CANCER
PH 3 STUDY TO EVAL PF-08634404 IN COMBINATION W/ CHEMOTHERAPY VS BEVACIZUMAB IN COMBINATION W/ CHEMOTHERAPY IN TREATMENT-NAÏVE PARTICIPANTS W/ METASTATIC COLORECTAL CANCER
GS-US-741-7756: A Phase 2, Open Label, Multicenter, Randomized Study, to Evaluate the Efficacy and Safety of Denikitug Monotherapy and Denikitug-based Combinations in Participants With Advanced Microsatellite Stable (MSS) Colorectal Cancer (CRC)
Ph 2 Study Evaluate the Efficacy & Safety of Denikitug Monotherapy a& Denikitug-based Combinations in Pts w/ Advanced Microsatellite Stable (MSS) Colorectal Cancer (CRC)
INCA033890-303: A Randomized, Double-Blind, Phase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
A RPhase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With/Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
NRG-GI008: This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.
Phase 2/3 trial will evaluate which chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer
PLN-10195-ONC-101: A Phase 1a/1b Multicenter, Open-label Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of PLN-101095 as Monotherapy and in Combination With Pembrolizumab in Adult Participants With Advanced or Metastatic Solid Tumors Who Have Disease Progression While on an Immune Checkpoint Inhibitor (FORTIFY)
Ph 1a/1bStudy of Antitumor Activity ofPLN-101095 as Monotherapy &ComboW/Pembrolizumab in Adult Pts W/ Adv/Met Solid Tumors W/Disease Prog &on an ImmuneCheckpointInhibitor
SGNTUC-029 (MOUNTAINEER-03): An Open-label Randomized Phase 3 Study of Tucatinib in Combination with Trastuzumab and mFOLFOX6 versus mFOLFOX6 given with or without either Cetuximab or Bevacizumab as First-line Treatment for Subjects with HER2+ Metastatic Colorectal Cancer
If tucatinib w/ other cancer drugs works better than SOC to treat HER2 positive colorectal cancer. Also looks at side effects that happen with this combination of drugs.

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