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Pooled Phase 3 (Cohort 1) and Phase 2 (Cohort 1A) To evaluate the virologic efficacy of REGN10933+REGN10987 compared to placebo in reducing viral load of SARS-CoV-2 To evaluate the clinical efficacy of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation Phase 1/2 (Cohort 1) To exclude futility of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation To evaluate the safety and tolerability of REGN10933+REGN10987 compared to placebo
A study to research the experimental drugs REGN10933 and REGN10987, given together as a treatment for people with COVID-19. The study is focused on people who have COVID-19 but do not need to be in the hospital.
A study to evaluate the efficacy of Remdesivir in reducing the rate of all-cause medically attended visits or death in non-hospitalized participants with early stage COVID-19. To evaluate the safety of Remdesivir administered in an outpatient setting.
This research study is looking at experimental drugs to prevent the COVID-19 disease from occurring in people who have been exposed to the SARS-CoV-2 virus. The goals of the study is to see if REGN10933+REGN10987 lowers infection by the virus, whether they reduce the need for medical visits and the amount of time spent away from your day-to-day activities (i.e., work, school, caring for others) due to COVID-19, and whether they can cause side effects.
Prospective, multi-center, double-blind, randomized, controlled trial evaluating nirmatrelvir/ritonavir (Paxlovid) in two dosing durations for the treatment of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC).