Blood and Marrow Transplant and Cellular Therapy

When you or a loved one battle a blood cancer such as aplastic anemia, leukemia, lymphoma (Hodgkin’s and non-Hodgkin’s), multiple myeloma or myelodysplastic syndrome, rebuild your immune system with an infusion of healthy stem cells through a blood and marrow transplant or cellular therapy at the Avera Cancer Institute Sioux Falls – the region’s only blood and marrow transplant program.

From a patient's immune cells or universal immune cells, cellular therapies engineer new cancer targets and then infuse them into the patient so these cells better attack cancer cells.

Advanced Transplant Expertise

After high-intensity chemotherapy or radiation therapy kills cancer cells, transplanting healthy blood and marrow cells helps fight disease.

Let Avera’s expert team offer guidance about the value of blood and marrow transplant for your specific situation. If you’re eligible, they’ll help you explore transplant options and identify the best ones for you. Approaches include:

  • Self-donation of stem cells (autologous blood and marrow transplant)
  • Stem cell donation from a donor matched by blood and genetic type (allogeneic blood and marrow transplant)

The Avera Cancer Institute in conjunction with the Avera Transplant Institute is a designated Transplant Center by the National Marrow Donor Program. This means you gain access to a worldwide listing of potential blood and marrow donors, which may widen your options and speed your treatment.

Blood and Marrow Transplant Resources

Find the support you need through a BMT Connections support group. Whether you’re a blood and marrow transplant patient or loved one, join us before, during and after the transplant procedure for discussion and encouragement.

Become a Blood and Marrow Donor

Help meet the need for healthy stem cells by becoming a blood and marrow donor. Avera McKennan Hospital & University Health Center is the only National Marrow Donor Program-approved apheresis stem cell collection center in South Dakota.

Each year, thousands of Americans are diagnosed with life-threatening diseases such as leukemia or lymphoma, for which a blood and marrow transplant may be the best and only hope for a cure. However, only 30 percent of people will find a suitable donor within their family. For the remaining 70 percent, an unrelated donor with a matching tissue type must be found.

To get started or find more information, visit Be The Match.

CAR-T Cell Therapy

For high-risk relapsed patients with diffuse large B-cell lymphoma or acute lymphoblastic leukemia, Avera is pioneering cutting-edge immunotherapy treatments. CAR-T cell therapy is a referral-based immunotherapy that uses a patient’s own modified T-cells to find and fight cancer cells.

CAR-T cell therapy removes a portion of your own blood cells, extracts T-cells and sends those to a lab to be manufactured to include special proteins called Chimeric Antigen Receptors (CARs). These proteins on the surface of your T-cells help them find and fight cancer cells. Manufactured cells are infused back into your body to help your immune system to fight the cancer.

CAR-T cell therapy is FDA approved for those who’ve failed prior therapies or transplants, and have experienced two or more cancer relapses.

As a sole provider of CAR-T cell therapy in the region, Avera Cancer Institute Sioux Falls suggests asking your hematologist about your options, side effect risks and insurance coverage.

Contact Us

Questions about bone marrow transplant? Call 800-657-4377.


Blood and Marrow Transplant Accreditation

fact accreditation logoAvera’s blood and marrow transplant program is fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT).

Become a Donor

Give an amazing gift by becoming an organ or blood and marrow donor. Review our donor services information to learn how you can:

Avera is a health ministry rooted in the Gospel. Our mission is to make a positive impact in the lives and health of persons and communities by providing quality services guided by Christian values.